Glucose and pH Dual‐Responsive Nanogels for Efficient Protein Delivery
نویسندگان
چکیده
منابع مشابه
Nanogels for intracellular delivery of biotherapeutics.
Many biomolecules, such as proteins and genes, are presently used as therapeutics. However, their delivery to target sites inside cells is challenging because of their large molecular size, difficulties to pass cellular membranes and their susceptibility for enzymatic and chemical degradation. Nanogels, three-dimensional networks of hydrophilic polymers, are attractive carrier systems for these...
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pH-Degradable PVA nanogels, which are prepared by photo-crosslinking thermo-preinduced PVA nanoaggregates in water without any surfactants or toxic organic solvents, are used for intracellular PTX release and anticancer treatment. These nanogels fast degraded at mildly acidic conditions with a pH-triggered PTX release, and the degradation products are only native PVA and poly(hydroxyethyl acryl...
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ژورنال
عنوان ژورنال: Macromolecular Bioscience
سال: 2020
ISSN: 1616-5187,1616-5195
DOI: 10.1002/mabi.202000243